Bayesian Modeling in Bioinformatics (Chapman & Hall/CRC by Dipak K. Dey,Samiran Ghosh,Bani K. Mallick

By Dipak K. Dey,Samiran Ghosh,Bani K. Mallick

Bayesian Modeling in Bioinformatics discusses the advance and alertness of Bayesian statistical equipment for the research of high-throughput bioinformatics info bobbing up from difficulties in molecular and structural biology and disease-related scientific study, corresponding to melanoma. It offers a large evaluation of statistical inference, clustering, and category difficulties in major high-throughput structures: microarray gene expression and phylogenic analysis.

The booklet explores Bayesian thoughts and types for detecting differentially expressed genes, classifying differential gene expression, and picking out biomarkers. It develops novel Bayesian nonparametric methods for bioinformatics difficulties, size blunders and survival types for cDNA microarrays, a Bayesian hidden Markov modeling procedure for CGH array info, Bayesian ways for phylogenic research, sparsity priors for protein-protein interplay predictions, and Bayesian networks for gene expression facts. The textual content additionally describes functions of mode-oriented stochastic seek algorithms, in vitro to in vivo issue profiling, proportional dangers regression utilizing Bayesian kernel machines, and QTL mapping.

Focusing on layout, statistical inference, and knowledge research from a Bayesian point of view, this quantity explores statistical demanding situations in bioinformatics info research and modeling and provides suggestions to those difficulties. It encourages readers to attract at the evolving applied sciences and advertise statistical improvement during this zone of bioinformatics.

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